![]() If you are taking a ritonavir- or cobicistat-containing medicine to treat hepatitis C or Human Immunodeficiency Virus (HIV), you should continue to take your medicine as prescribed by your healthcare provider. You may need frequent blood tests to check your liver function. Swallow the tablets whole and do not crush, chew, or break them. You may take Paxlovid with or without food. Take Paxlovid as soon as possible after diagnosis of COVID-19 and within 5 days of when symptoms first appear. If you have kidney disease, talk to your healthcare provider. Take nirmatrelvir together with ritonavir (two tablets of nirmatrelvir and one tablet of ritonavir) twice a day for 5 consecutive days. Paxlovid pregnancy and breastfeeding warnings (more detail) How should I take Paxlovid?įollow all directions on your prescription label and read all medication guides or instruction sheets. Talk to your healthcare provider about the best way to feed your baby during treatment withthis medicine. It is not known if Paxlovid can pass into your breast milk. Tell your healthcare provider are breastfeeding or plan to breastfeed. Ask your doctor about other birth control options such as an injection, implant, vaginal ring, condom, diaphragm, cervical cap, or contraceptive sponge. Ritonavir can make birth control pills or skin patches less effective. It is not known if Paxlovid can harm your unborn baby. Tell your healthcare provider right away if you are or if you become pregnant. you have any serious or chronic disease.you have liver problems or a liver disease such as hepatitis.seizure medicine- carbamazepine, phenobarbital, phenytoin.Paxlovid should not be started immediately after discontinuation of any of the following drugs: a sedative- triazolam, oral midazolam.cholesterol-lowering medicine- lovastatin, simvastatin or.ergot medicine- dihydroergotamine, ergotamine, methylergonovine.antipsychotic medicine- lurasidone, pimozide, clozapine.heart medicine- amiodarone, dronedarone, flecainide, propafenone, quinidine, ranolazine.pain medicine-pethidine, piroxicam, propoxyphene.sildenafil ( Revatio) when used to treat pulmonary arterial hypertension (PAH).Some drugs should not be used with Paxlovid, such as those listed below. Click here for a full list of Paxlovid ingredients. You should not use Paxlovid if you are allergic to the active ingredients nirmatrelvir and ritonavir, or any of the inactive ingredients. Related/similar drugs molnupiravir, remdesivir, Actemra, Lagevrio, nirmatrelvir / ritonavir, Olumiant Before taking this medicine Older people and people of all ages with severe, long-lasting (chronic) medical conditions like heart disease, lung disease, and diabetes, for example, seem to be at higher risk of being hospitalized for COVID-19. While information so far suggests that most COVID-19 illness is mild, serious illness can happen and may cause some of your other medical conditions to become worse. COVID-19 illnesses have ranged from very mild to severe, including illness resulting in death. You can get COVID-19 through close contact with another person who has the virus. What is COVID-19?ĬOVID-19 is caused by a virus called coronavirus. Ritonavir is co-administered with nirmatrelvir to help slow its metabolism in order for it to remain active in the body for longer periods of time at higher concentrations to help combat the virus. Nirmatrelvir is a SARS-CoV-2 main protease (Mpro) inhibitor (also known as SARS-CoV2 3CL protease inhibitor) that works by inhibiting viral replication in the early stages of the disease to prevent progression to severe COVID-19. Paxlovid contains two medicines: nirmatrelvir and ritonavir. Paxlovid is not approved or authorized for use as a pre-exposure or post-exposure prophylaxis for the prevention of COVID-19. It may also be prescribed for an individual patient by a state-licensed pharmacist under specific conditions. Paxlovid may be prescribed for an individual patient by physicians, advanced practice registered nurses, and physician assistants that are licensed or authorized under state law to prescribe drugs. ![]() ![]() It is taken to decrease the number and severity of symptoms or avoid severe illness, which may lead to hospitalization or death. Paxlovid should be taken as soon as possible after diagnosis of COVID-19. Paxlovid is available under an Emergency Use Authorisation (EUA) to treat patients 12 to 18 years old for mild-to-moderate COVID-19 who are at high risk for progression to severe COVID-19, including hospitalization or death. Paxlovid (nirmatrelvir tablets co-packaged with ritonavir tablets) is an FDA-approved medicine to treat adults with mild-to-moderate COVID-19 and who are at high risk for progression to severe COVID-19, including hospitalization or death. Medically reviewed by Melisa Puckey, BPharm. Dosage form: tablets, co-packaged for oral use ![]()
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